Special presentation of aminopolysaccharide quaternary ammonium salt

2022/07/25

1. Concept
1-1 Aminopolysaccharide
Aminopolysaccharide, also known as mucopolysaccharide, acid mucopolysaccharide, connective tissue polysaccharide, etc., is a type of polysaccharide containing amino groups in animals and an important macromolecular substance in animals. Such macromolecules play an important role in connective tissue and are an important component of the amorphous matrix of connective tissue. They control the transport of various motor molecules and have a profound impact on the metabolic process of cells and tissues in the body.
Studies have found that aminopolysaccharides play an important role in maintaining the overall structure of tissues and bodies and maintaining the stability of extracellular fluid. The network structure formed by aminopolysaccharide can prevent the invasion of bacteria and viruses, protect the tissue, and promote wound healing.
Aminopolysaccharides play an important role in many biological, physiological and pathological processes, and have attracted widespread attention in the world's medical community. Existing studies have found that aminopolysaccharides can be widely used in industry, medicine, health care, food processing and other fields.
1-2 Quaternary ammonium salt
Quaternary ammonium salt, also known as quaternary ammonium salt, has similar properties to inorganic salts, is easily soluble in water, and the aqueous solution can conduct electricity. It is mainly prepared by the reaction of ammonia or amine with halogenated alkyl.
Many quaternary ammonium salts existing in nature have certain biological activities, and some quaternary ammonium salts can be used as drugs, pesticides and phase transfer catalysts in chemical reactions.
The functions of quaternary ammonium salts include: agricultural fungicides, sterilization and disinfection of public places, circulating water sterilization and algaecide, aquaculture sterilizers, medical sterilizers, livestock and poultry house disinfectants, red tide fungicides, cyanobacteria fungicides, etc. Sterilization and disinfection field. In particular, Gemini quaternary ammonium salt has outstanding bactericidal effect and low comprehensive cost.
Quaternary ammonium salt products have been developing in the direction of green environmental protection, easy biodegradation, and no APEO, formaldehyde and other hazards to the natural environment and human health. With the improvement of public awareness and the requirements of environmental quality, such products continue to meet the needs of social development. It is an inevitable direction for the future development of the surfactant industry.
1-3 Aminopolysaccharide Quaternary Ammonium Salt
Amino polysaccharide quaternary ammonium salt is formed by the reaction of natural pupa extract and amino compounds. After microfiltration, ultrafiltration, reverse osmosis, spray drying and static drying, the ability to activate and repair cells is enhanced, and the adsorption is efficient. , film formation. Significantly improved the antibacterial effect, and also achieved long-acting (3 days/72 hours) sustained release control. A formula that integrates multiple functions has been realized.
In medicine, it is mainly used in the fields of antibacterial wounds, anticoagulation, sustained-release drug loading, and skin induction. The aminopolysaccharide quaternary ammonium salt solution is colorless or light yellow, uniform in color, tasteless and odorless, and the pH is between 5.0-7.0.
Second, the role of aminopolysaccharide quaternary ammonium salt
2-1 How it works
The carboxylation of aminopolysaccharides is mainly achieved by the reaction of glyoxylic acid with -OH or -NH2 groups of chitosan, and carboxylated chitosan derivatives have -COOH and -NH2 amphiphilic groups (Figure 3). Under the condition of protonation, the carboxymethyl chitosan is positively charged; in the alkaline condition, the ionization of the carboxyl group makes the carboxymethyl chitosan negatively charged, and its water solubility is mainly affected by the degree of substitution. Carboxylated chitosan derivatives have strong mucoadhesion and are often used as mucosal drug delivery carriers, and are widely used in oral, intestinal, and vaginal mucosal delivery.